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KMID : 1143620180220020097
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Korean Journal of Nuclear Medicine Technology
2018 Volume.22 No. 2 p.97 ~ p.100
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Glomerular Filtration Rate Test Methods and Guidelines
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Park Min-Ho
Lee Ha-Young
Ryu Hwa-Jin
Yoo Tae-Min
Noh Kyeong-Woon
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Abstract
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Purpose : The glomerular filtration rate (GFR) test is an important indicator of glomerular filtration and has been used to test renal function and the extent of its function. The GFR test is performed by intravenous injection of radioactive medicines made of 51Cr-EDTA, and blood concentration is measured by taking blood according to the elapsed time. also, PET-CT, bone scan, transfusion and so on will affect the outcome. Therefore, we will improve the quality of the test by providing guidelines for the GFR test for more accurate testing.
Materials and Methods : 5 mL of physiological saline solution and 2 mL of 51Cr-EDTA solution are used to make 5 mL of the radiopharmaceutical solution to be injected into the patient. First, the syringe weight is measured before the injection, and then the radioactive medicine is injected into the patient's vein and the syringe weight is measured after the injection. Blood sampling is performed twice in total. In adults, blood is collected 3 hours / 5 hours after injection and in children 2 hours / 5 hours after injection. The blood sample is centrifuged at 3300 rpm for 5 minutes. Standard solution is prepared by filling diluent water up to the scale indicated in the 200-mL volumetric flask, discarding 500 μL, injecting 500 μL of GFR reagent and mixing well. 500 μL each of the standard solution is dispensed into two test tubes, and 500 μL of each of the plasma samples collected in time is dispensed into two test tubes and measured with a Cobra Counter.
Results : At present, the reference range applied in this study is 119.5 ± 30.3 ml / min / 1.73m2 for males and 125.2 ± 28.2
ml / min / 1.73m2 for females.
Conclusion : The GFR test is conducted using radioactive medical products. GFR testing is performed as a scheduled test, but PET-CT, dialysis and transfusion, which may affect GFR testing, may be scheduled during GFR testing.Therefore, we could get accurate GFR test results by notifying the ward and department beforehand when booking.
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KEYWORD
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Glomerular filtration rate , 51Cr-EDTA , Cobra Counter
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